Wound Healing

Wound healing is the body’s natural process of regenerating and repairing dermal and epidermal tissue. This healing occurs with a combination of both regeneration and repair. Repair results in a patch of tissue that has neither the function nor the esthetic of the original tissue. The purpose of the patch, or scar, is to allow the surrounding, undamaged tissue to function as normally as possible. The scar forms through the recruitment of scaffold forming cells called fibrocytes and fibroblasts, and deposition of collagen. In contrast, regeneration allows a restoration of both the form and the function of the original tissue.

GliaMed has discovered that treating wounds with RILs tips the body’s healing system toward regeneration, resulting in a remarkable reformation of normal tissue at sites of damage. In animal studies, RIL-treated full-thickness wounds have been shown to fully heal and develop all the complex skin structures, including nerves, hair follicles, sweat glands, dermis and epidermis, in less than half the time of untreated wounds.

In addition to the expected benefits of accelerated wound closure and reduced risk of infection, GliaMed’s topical RIL product has the potential to reduce or eliminate scarring, which can cause significant loss of function in patients who have recovered from extensive burns, whether from thermal, radiation or chemical sources. In addition, the company is evaluating the potential application of its topical product in patients undergoing cosmetic or orthopedic surgery and in the treatment of keloid scars.